改变心血管护理和心力衰竭的负担

At AstraZeneca, we believe we play a pivotal role in advancing the understanding of HF and driving better patient outcomes. 通过与世界各地的医疗保健系统合作，澳门葡京赌博游戏的目标是到2030年减少 heart failure related 入院人数减少50%，过早死亡人数减少20%. 通过全球合作倡议, 澳门葡京赌博游戏的目标是减轻心衰患者的负担, healthcare systems and society.

心衰是一种复杂的进行性疾病

心衰是一种长期的急性疾病，随着时间的推移，心脏变得太弱或僵硬，无法泵出足够的血液来满足身体的需要，病情就会恶化, 导致身体和精神上的虚弱症状.^1,4 心衰患者常出现呼吸短促, fatigue, swelling in legs, sleep disturbances, chest pain and depression.^4,7 这些症状严重影响日常活动, resulting in compromised quality of life and high hospitalisation and mortality rates.^4,8-10

Beyond the impact of HF on patients, 它还给医疗保健系统带来了沉重的经济负担. 全球范围内，心力衰竭的费用估计为346美元.17 billion, with projections indicating a staggering 127% increase in HF costs by 2030.^11,12 Hospitalisations, 负责高达87%的费用, 是心衰相关医疗费用的主要驱动因素.¹

心衰常被误诊，诊断延误，死亡率高

Studies have shown symptoms of HF can manifest up to five years before an official diagnosis, affecting over 40%* of patients.¹³ 大约75%*的心衰病例不幸是在医院环境中发现的.¹⁴ 但约46%**的心衰患者在急性护理机构诊断前曾向初级保健医生报告过症状.¹⁵

The consequences of delayed HF diagnosis can lead to significantly poor clinical outcomes. 在诊断时，延迟检测常常导致更严重的心衰, hindering access to preventive medications and leading to an increase in cardiovascular events and hospitalisations.¹⁶

Despite advancements in HF treatment and prevention, morbidity and mortality rates remain high. Within just one year of an HF diagnosis, 24-33% of patients die from the condition.⁵ Despite its prevalence and impact, however, public awareness of HF remains relatively low.^1,17

Who is at risk for HF?

心衰的病因和受影响的心脏区域各不相同, but a person is at increased risk if they have a history of coronary artery disease, heart attacks, chronic kidney disease (CKD), diabetes or hypertension.^18-20

生活方式也会增加心衰的风险, 特别是对于那些有既存状况的人. 这些行为包括吸烟, eating foods high in fat, cholesterol, and sodium, and physical inactivity.^21,22

早期的心衰诊断可以减缓病情进展，并有助于控制合并症

Early detection of HF plays a crucial role in preventing poor clinical and patient outcomes.²¹ Timely diagnosis allows for early intervention and access to appropriate treatments, 哪些可以减缓疾病的进展，提高生活质量.^4,21 医疗指南和指南导向的医疗疗法(GDMT)是解决方案的重要组成部分，因为它们有助于为临床医生提供以患者为中心的建议，以诊断和管理患者.²²

For HF care teams, 医学指南包括欧洲心脏病学会(ESC)急性和慢性心力衰竭诊断和治疗指南和美国心脏病学会/美国心脏协会/美国心力衰竭学会心力衰竭管理指南.^3,22 这些指南对不同类型的心衰提供了见解, ways to approach the disease, 以及早期诊断和干预的建议.^2,22

Delayed diagnosis, however, 在诊断时是否会导致更严重的心衰, 这使得有效管理病情变得具有挑战性.¹⁷ 较晚获得预防性保健和干预措施也可能导致错过处理风险因素和实施预防心衰恶化措施的机会.¹⁷ 这强调了及时筛查和诊断的重要性，以确保患者尽早获得必要的护理和支持.^2,17

合并症的存在增加了心衰治疗的复杂性. Many HF patients have other concurrent medical conditions such as high blood pressure, diabetes or CKD.^2,24,25 These comorbidities can further impact the clinical outcomes and treatment approaches for HF patients. 在为心衰患者制定综合管理计划时，医疗保健提供者考虑这些附加条件是至关重要的. 通过利用指南和GDMT来解决HF和合并症, healthcare professionals can optimise treatment strategies and improve patient outcomes.^2,22

澳门葡京赌博游戏对心衰患者的承诺

澳门葡京赌博游戏认为自己是心衰医疗保健的核心部分，并与心血管社区合作，改变心衰护理的交付. By 2030, our ambitious goal is to reduce HF mortality rates by 20% and HF-related hospitalisations by 50%. 澳门葡京赌博游戏的目标是将指南导向药物治疗(GDMT)的使用率从2020年的不到5%提高到2025年的35%.

To realise this ambition, 澳门葡京赌博游戏启动了心衰共同加速变革(ACT)计划，以推动整个医疗保健生态系统的心衰全面变革. Through ACT on HF, we aim to elevate HF as a healthcare priority and highlight the development of national strategies. We’re also working to support healthcare providers (HCPs) to enhance prevention and diagnosis capabilities, and partner with them to improve HF management and ensure all HF patients receive optimal and integrated care.

Increasing awareness and education on HF and GDMT are particularly important components of ACT on HF, as early detection and intervention can help patients receive optimal guideline-directed care.²³ 自2020年在HF上启动ACT以来, 据澳门葡京赌博游戏估计，澳门葡京赌博游戏已经为提高8000多万人的心衰意识做出了贡献，并为400多人提供了支持,000 HCPs receiving HF education.

鼓励尽早进行心衰筛查和诊断的项目

To drive change in HF, we are working together with global, regional and local partners. Through our collaborative efforts, 澳门葡京赌博游戏的目标是实施创新方法, leverage the latest technologies, 并采取大规模行动，提高早期诊断率，改善全球HF患者的生活.

We are committed to expanding understanding around HF and have generated real-world evidence on:

患者授权是心衰干预的关键

In addition to disease awareness, we prioritise patient empowerment and help amplify their voices through publications in peer-reviewed journals. As part of our ACT on HF initiative, 澳门葡京赌博游戏支持一篇与心脏病专家共同撰写的文章，鼓励HCPs与心衰患者之间更密切的合作，以突出心衰患者的挑战和机遇.²⁶

Through our collaborations, we actively support initiatives that encourage individuals living with HF to self-manage their care. 这些举措包括为患者提供资源, 有效管理其健康所需的工具和教育材料，包括将其与ESC患者自我管理心衰指南等材料联系起来.²⁷

HF需要立即采取协作行动

Through joint efforts, we can make a profound difference and forge a future with improved HF outcomes for all. The complexities of HF require the entire cardiovascular community to transform HF management and care.  澳门葡京赌博游戏坚定不移地致力于改变心衰，为全世界的患者实现可持续的改变.
 

*Data refers to a UK population
**Data refers to a US population

Veeva ID: Z4-57460
Date of preparation: August 2023