通过合作推动癌症研究创新

写的:

Ezogelin Oflazoglu-Gruyters

对外事务副总裁&D和创新,澳门葡京网赌游戏

在澳门葡京网赌游戏, we recognise the importance of collaborating with scientific experts 和 institutions around the world. We are committed to creating mutually beneficial partnerships that help us deliver our ambition of eliminating cancer as a cause of death, 包括改善早期发现和诊断, 开发创新的治疗方案, 改善所有癌症患者的治疗效果.


肿瘤研究中合作的重要性 & 发展

澳门葡京赌博游戏在肿瘤学领域有着丰富的创新历史. 在澳门葡京赌博游戏消除癌症这一致死原因的雄心壮志的推动下, we have made tremendous progress in translating science into innovative medicines to potentially bring cures within reach. 这是由澳门葡京赌博游戏肿瘤学R&D战略 of advancing a diverse 管道 to attack cancer from multiple angles 和 changing outcomes through earlier detection 和 treatment.

However, bold ambitions require bold 创新, 和 we cannot achieve this alone. 通过合作, 澳门葡京赌博游戏可以利用尖端技术, 新型临床前模型, patient samples 和 clinical data that complement our in-house expertise 和 capabilities. These collaborations help us stay at the forefront of science to deliver the next wave of potentially transformational cancer treatments.

澳门葡京赌博游戏的 外部R&D和创新团队 推动这些合作的创造和发展, 在澳门葡京赌博游戏的肿瘤学研究中发挥着不可或缺的作用&D策略由:

  • 领导外部活动, 包括由重要外部专家组成的科学小组, to obtain feedback 和 insights to shape our 发展 programmes 和 disease area strategies
  • 确定有能力的学术合作伙伴, 创新技术, 和 biosamples aligned to support our strategic areas of focus 和 establishing new collaborations 和 research agreements
  • Fostering mutually beneficial relationships with laser-focus on accelerating early clinical 发展 of potentially life-changing medicines to patients

Advancing our clinical strategy through oncology partnerships: 澳门葡京赌博游戏的 Partners of Choice Network


Through our current partnerships with cancer centres 和 academic institutes, we have gained access to cutting-edge technologies 和 expertise that are driving new insights in our research. 澳门葡京赌博游戏在促进合作方面最令人兴奋的举措之一是 选择伙伴(PoC)网络.1

由九个国际癌症中心组成, the Partners of Choice Network brings together leading institutes at the forefront of 创新. 通过共享数据, 洞察力和技术相互结合, we’re increasing scientific exchange between global sites 和 enhancing the translational research 和 clinical capabilities of all members.1

重要的是, 该网络提供了获取患者样本的途径, enabling translational research that is critical to developing our future oncology portfolio.

Dr. Violeta塞拉, who worked in collaboration with 澳门葡京网赌游戏 to further our clinical oncology research




例如,澳门葡京赌博游戏可以访问 纪念斯隆凯特琳癌症中心的MSK-IMPACT (Integrated Mutation Profiling of Actionable Cancer Targets) database through the network.2 这使澳门葡京赌博游戏最近能够分析来自7的数据,000-patient cohort to identify mechanisms of resistance to endocrine therapy in ER+ breast cancer.2

澳门葡京赌博游戏也有一个重要的伙伴关系 瓦尔德希伯伦肿瘤研究所(VHIO) 在西班牙,这一直是推动有前途的转化研究的关键. Dr. 来自VHIO的Violeta塞拉与Dr. Mark O 'Connor, Discovery 肿瘤学R的首席科学家&D, 澳门葡京网赌游戏, 领导鉴定了一种新的生物标志物, RAD51, 这可以预测对某些癌症治疗的耐药性.3 This is being used across our clinical programmes to measure the functionality of the DNA Damage Response (DDR) in patients 和 predict how well they might respond to different DDR therapies.3

 

与外部科学专家合作,为澳门葡京赌博游戏的肿瘤学战略提供信息

We have more than 700 active agreements with partners who are helping us identify 和 explore novel targets, 治疗方案等.

博士之间的合作. 缬草E. Kagan, professor at the University of Pittsburgh School of Public Health, 和 Dr. 德米特里•我. Gabrilovich, 执行董事, 首席科学家, 澳门葡京网赌游戏的癌症免疫学, led to a recent publication describing the immune suppressive role of the ferroptosis pathway in cancer.4  他们的工作导致了新的治疗靶点的发现, 包括肿瘤微环境中的骨髓细胞.4 这些发现正在推动澳门葡京赌博游戏的研究的进一步发展 免疫疗法 管道.

外部研究的未来 & 发展与创新

We are harnessing the latest 创新s to accelerate the delivery of potential life-changing therapies to patients. 展望未来,澳门葡京赌博游戏将重点关注:

  • 继续访问 外部洞察,数据,样本 创新 通过对外合作、战略联盟和PoC网络
  • Exp和ing our alliances 和 collaborations that allow us to harness advances in AI 对R进行变换&D,提供新的医疗保健解决方案
  • 增进澳门葡京赌博游戏对这个角色的理解 肿瘤克隆进化 肿瘤间质 在癌症中寻找新的方法来破坏它
  • 扩大澳门葡京赌博游戏的合作,更加注重 中国与亚太(APAC)学术生态系统 将这些地区的创新成果带给全球患者

As our work progresses, we know there will be challenges that we can’t overcome alone. Strategic collaborations are integral to our success 和 in our pursuit to redefine cancer care for patients. That’s why we’re always seeking new opportunities to exp和 our network 和 ignite bold 创新. 



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参考文献
 

1. 吉布斯一. 澳门葡京网赌游戏 selects OHSU Knight Cancer Institute as global ‘partner of choice’. 可在:http://news.也是ohsu.edu/2020/10/29/astrazeneca-selects-也是ohsu-knight-cancer-institute-as-global-partner-of-choice . 于2024年1月发布.

2. 陈建军,李建军,李建军,等. FOXA1 Mutations Reveal Distinct Chromatin Profiles 和 Influence Therapeutic Response in Breast Cancer. 癌症细胞. 2020;38(4):534-550.

3. 张建军,张建军,张建军,等. A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation. EMBO Mol Med. 2018;10(12):e9172.

4.  李建军,李建军,李建军,等. 肿瘤中性粒细胞的铁下垂引起癌症的免疫抑制. 自然. 2022;612:338-346.


Veeva ID: Z4-61844
筹备日期:2024年2月